Thursday, February 7, 2013

Device made of DNA inserted into bacterial cell works like a diagnostic computer

Feb. 6, 2013 ? Scientists hope that one day in the distant future, miniature, medically-savvy computers will roam our bodies, detecting early-stage diseases and treating them on the spot by releasing a suitable drug, without any outside help. To make this vision a reality, computers must be sufficiently small to fit into body cells. Moreover, they must be able to "talk" to various cellular systems. These challenges can be best addressed by creating computers based on biological molecules such as DNA or proteins. The idea is far from outrageous; after all, biological organisms are capable of receiving and processing information, and of responding accordingly, in a way that resembles a computer.

Researchers at the Weizmann Institute of Science have recently made an important step in this direction: They have succeeded in creating a genetic device that operates independently in bacterial cells. The device has been programmed to identify certain parameters and mount an appropriate response.

The device searches for transcription factors -- proteins that control the expression of genes in the cell. A malfunction of these molecules can disrupt gene expression. In cancer cells, for example, the transcription factors regulating cell growth and division do not function properly, leading to increased cell division and the formation of a tumor. The device, composed of a DNA sequence inserted into a bacterium, performs a "roll call" of transcription factors. If the results match preprogrammed parameters, it responds by creating a protein that emits a green light -- supplying a visible sign of a "positive" diagnosis. In follow-up research, the scientists -- Prof. Ehud Shapiro and Dr. Tom Ran of the Biological Chemistry and Computer Science and Applied Mathematics Departments -- plan to replace the light-emitting protein with one that will affect the cell's fate, for example, a protein that can cause the cell to commit suicide. In this manner, the device will cause only "positively" diagnosed cells to self-destruct.

In the present study, published in Nature's Scientific Reports, the researchers first created a device that functioned like what is known in computing as a NOR logical gate: It was programmed to check for the presence of two transcription factors and respond by emitting a green light only if both were missing. When the scientists inserted the device into four types of genetically engineered bacteria -- those making both transcription factors, those making none of the transcription factors, and two types making one of the transcription factors each -- only the appropriate bacteria shone green. Next, the research team -- which also included graduate students Yehonatan Douek and Lilach Milo -- created more complex genetic devices, corresponding to additional logical gates.

Following the success of the study in bacterial cells, the researchers are planning to test ways of recruiting such bacteria as an efficient system to be conveniently inserted into the human body for medical purposes (which shouldn't be a problem; recent research reveals there are already 10 times more bacterial cells in the human body than human cells). Yet another research goal is to operate a similar system inside human cells, which are much more complex than bacteria.

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The above story is reprinted from materials provided by Weizmann Institute of Science.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Tom Ran, Yehonatan Douek, Lilach Milo, Ehud Shapiro. A programmable NOR-based device for transcription profile analysis. Scientific Reports, 2012; 2 DOI: 10.1038/srep00641

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_environment/~3/8AwaP2UQvUU/130207074254.htm

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Family of Ala. hostage 'ecstatic' after boy's release

The 5-year-old boy held hostage in a nearly week-long standoff in Alabama is in good spirits and apparently unharmed after being reunited with his family at a hospital, according to his family and law enforcement officials.

The boy, identified only as Ethan, was rescued by the FBI Monday afternoon after they rushed the underground bunker where suspect Jimmy Lee Dykes, 65, was holding him. Dykes was killed in the raid and the boy was taken away from the bunker in an ambulance.

Ethan's thrilled relatives told "Good Morning America" today that he seemed "normal as a child could be" after what he went through and has been happily playing with his toy dinosaur.

"He's happy to be home," Ethan's great uncle Berlin Enfinger told "GMA." "He's very excited and he looks good."

Click here for a psychological look at what's next for Ethan.

"If I could, I would do cartwheels all the way down the road," Ethan's aunt Debra Cook said. "I was ecstatic. Everything just seemed like it was so much clearer. You know, we had all been walking around in a fog and everyone was just excited. There's no words to put how we felt and how relieved we were."

Cook said that Ethan has not yet told them anything about what happened in the bunker and they know very little about Dykes.

What the family does know is that they are overjoyed to have their "little buddy" back.

"He's a special child, 90 miles per hour all the time," Cook said. "[He's] a very, very loving child. When he walks in the room, he just lights it up."

Officials have remained tight-lipped about the raid, citing the ongoing investigation.

"I've been to the hospital," FBI Special Agent Steve Richardson told reporters Monday night. "I visited with Ethan. He is doing fine. He's laughing, joking, playing, eating, the things that you would expect a normal 5- to 6-year-old young man to do. He's very brave, he's very lucky, and the success story is that he's out safe and doing great."

Ethan is expected to be released from the hospital later today and head home where he will be greeted by birthday cards from his friends at school. Ethan will celebrate his 6th birthday Wednesday.

Officials were able to insert a high-tech camera into the 6-by-8-foot bunker to monitor Dykes' movements, and they became increasingly concerned that he might act out, a law enforcement source with direct knowledge told ABC News Monday. FBI special agents were positioned near the entrance of the bunker and used two explosions to gain entry at the door and neutralize Dykes.

Who Is Jimmy Lee Dykes?

"Within the past 24 hours, negotiations deteriorated and Mr. Dykes was observed holding a gun," the FBI's Richardson said. "At this point, the FBI agents, fearing the child was in imminent danger, entered the bunker and rescued the child."

Richardson said it "got tough to negotiate and communicate" with Dykes, but declined to give any specifics.

After the raid was complete, FBI bomb technicians checked the property for improvised explosive devices, the FBI said in a written statement Monday afternoon.

The FBI had created a mock bunker near the site and had been using it to train agents for different scenarios to get Ethan out, sources told ABC News.

Former FBI special agent and ABC News consultant Brad Garrett said rescue operators in this case had a delicate balance.

"You have to take into consideration if you're going to go in that room and go after Mr. Dykes, you have to be extremely careful because any sort of device you might use against him, could obviously harm Ethan because he's right there," he said.

Ethan's Family Feels Like Doing Cartwheels

Still, Monday's raid was not the ending police had sought as they spent days negotiating with the decorated Vietnam veteran through a ventilation shaft. The plastic PVC pipe was also used to send the child comfort items, including a red Hot Wheels car, coloring books, cheese crackers, potato chips and medicine.

State Sen. Harri Anne Smith said Ethan's mother asked police a few days ago not to kill Dykes.

"She put her hand on the officer's heart and said, 'Sir, don't hurt him. He's sick,'" Smith said Monday.

Taylor Hodges, pastor of the Midland City Baptist Church, said, "Many people here don't keep their doors locked. Things are going to change, especially for our school system."

The outcome of the situation drew praise from the White House.

"This evening, the president called FBI Director Robert Mueller to compliment him for the role federal law enforcement officers played in resolving the hostage situation in Alabama today," according to a statement from a White House official late Monday. "The president praised the exceptional coordination between state, local, and federal partners, and thanked all the law enforcement officials involved during the nearly week-long ordeal for their roles in the successful rescue of the child."

Dykes allegedly shot and killed a school bus driver, Albert Poland Jr., 66, last Tuesday and threatened to kill all the children on the bus before taking the boy, one of the students on the bus said Monday.

"He said he was going to kill us, going to kill us all," Tarrica Singletary, 14, told ABC News.

Dykes had been holed up in his underground bunker near Midland City, Ala., with the abducted boy for a week as police tried to negotiate with him through the PVC pipe. Police were careful not to anger Dykes, who was believed to be watching news reports from inside the bunker, and even thanked him at one point.

Dykes lived in Florida until two years ago, The Associated Press reported, and has an adult daughter, but the two lost touch years ago, neighbor Michael Creel said. When he returned to Alabama, neighbors say he once beat a dog with a lead pipe and had threatened to shoot children who set foot on his property.

ABC News' Mary Bruce and Michael S. James contributed to this report.

Also Read

Source: http://gma.yahoo.com/rescued-boys-family-feels-doing-cartwheels-072448093--abc-news-topstories.html

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Wednesday, February 6, 2013

Lawyers: NYPD's Muslim spying violates 1985 pact

(AP) ? Civil rights lawyers urged a judge Monday to stop the New York Police Department from routinely observing Muslims in restaurants, bookstores and mosques, saying the practice violates a landmark 1985 court settlement that restricted the kind of surveillance used against war protesters in the 1960s and '70s.

The city responded by saying it follows the law, but some legal experts say it might be time to look more closely at police practices as the Sept. 11 attacks fade into history.

"This filing is coming at the same time that I think Americans in general are beginning to see their way past the 9/11 era and the fears that engendered," said Karen Greenberg, director of the Center on National Security at Fordham Law School.

The court papers in U.S. District Court in Manhattan seek a court order against additional surveillance of Muslims without evidence of crimes and a new court-appointed auditor to oversee police activities that were "flagrant and persistent."

The civil rights lawyers complained that the NYPD has monitored public places where Muslims eat, shop and worship and has kept records and notes about their observations despite any evidence of unlawful or terror-related activities. The NYPD's actions violate rules, known as the Handschu guidelines, that a court imposed in the 1985 settlement, the lawyers said.

NYPD spokesman Paul Browne said in a statement: "The NYPD adheres to the Constitution in all it does, and specifically the Handschu guidelines in the deployment of undercover officers to help thwart plots against New York City and to identify individuals engaged in support of terrorism." The statement made no reference to informants, which the department has also used.

Browne added that terrorists have tried to attack New York City since the World Trade Center was destroyed, including plots to destroy the Brooklyn Bridge, to blow up the Federal Reserve Bank and to kill American soldiers returning home to New York.

City lawyer Celeste Koeleveld said the police department "considers the Handschu requirements carefully to ensure that all of its law enforcement actions conform to them."

The civil rights lawyers said there was "substantial evidence" that the police department had for years been using intrusive methods to conduct investigations into organizations and individuals associated with Islam and the Muslim community in New York even though there were no signs of unlawful activity.

NYPD Commissioner Raymond Kelly has said the department has plenty of oversight, including five district attorneys, a committee that investigates police corruption, the NYPD's own internal affairs office and the court-imposed Handschu guidelines.

In a speech last year to Fordham Law School alumni that was posted on the NYPD website, Kelly offered a spirited defense of its surveillance tactics, quoting the Handschu guidelines as saying that in pursuit of intelligence gathering: "The NYPD is authorized to visit any place and attend any event that is open to the public" and "to access online sites and forums on the same terms ... as members of the public."

He added: "Anyone who intimates that it is unlawful for the police department to search online, visit public places, or map neighborhoods has either not read, misunderstood, or intentionally obfuscated the meaning of the Handschu guidelines."

The NYPD is the largest police department in the nation, and Bloomberg has held up its counterterrorism tactics as a national model.

The spying was the subject of a series of stories by The Associated Press that revealed the NYPD intelligence division infiltrated dozens of mosques and Muslim student groups and investigated hundreds. The civil rights lawyers' new court motion refers repeatedly to the AP's reporting and includes some internal NYPD documents the AP had obtained and published.

The motion focuses on a particular section of the NYPD's intelligence division known initially as the Demographics Unit and later renamed the Zone Assessment Unit. This unit is at the heart of the NYPD's spying program, built with help from the CIA. It assembled databases on where Muslims lived, shopped, worked and prayed. Police infiltrated Muslim student groups, put informants in mosques, monitored sermons and catalogued every Muslim in New York who adopted new, Americanized surnames.

Supporters said the Demographics Unit was central to keeping the city safe, though a senior NYPD official testified last year that the unit never generated any leads or triggered a terrorism investigation.

Matthew C. Waxman, a professor at Columbia Law School who specializes in national security law and has spoken of the role of local police in anti-terrorism efforts, called counterterrorism "inherently and inevitably somewhat of a local police concern" because it's a threat to local security and because local police often have the relationships needed to uncover possible plots.

"On the other hand, aggressive police surveillance or even just perceived surveillance can alienate local communities and cause to dry up the very sources of information so critical to countering terrorism," he said.

Civil rights attorney Ron Kuby, who has represented several Muslims in connection with terrorism cases, said Kelly's calculus is probably shared by most New Yorkers: "If I over-police, I tread on civil liberties and people complain and file lawsuits. If I under-police, there's a smoking crater in Manhattan and thousands are dead. Gee, what should I do?"

He praised the civil rights lawyers for bringing the Handschu action, saying it was time to restore some of the "damage to the Constitutional fabric of America" after the Sept. 11 attacks.

But he added a little praise for Kelly, too: "I share the general feeling of the citizenry of saying he does a good job of making sure we haven't been blown up on our way to work."

The Handschu guidelines came out of a lawsuit the civil rights lawyers filed and a subsequent 1985 court settlement that set strict time limits for investigations, imposed rules on the kinds of records police could keep and created a three-person body to oversee such investigations.

Handschu was a reference to lead plaintiff Barbara Handschu in a case that included 1960s radical activist Abbie Hoffman among its plaintiffs.

It was not immediately clear when the judge will rule on the new motion.

___

Sullivan reported from Washington. Associated Press writer Colleen Long contributed to this report from New York.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/89ae8247abe8493fae24405546e9a1aa/Article_2013-02-04-NYPD-Intelligence-Lawsuit/id-58c2d8881d094d00b1f37aca33b4ad5f

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A Billion-Dollar Club, and Not So Exclusive

"I thought we were special," said Phil Libin, chief executive of Evernote, an online consumer service for storing clippings, photos and bits of information as he counted his $1 billion-plus peers.

He started Evernote in 2008 on the eve of the recession and built it methodically. "A lot of us didn't set out to have a big valuation, we're just trying to build something that lasts," Mr. Libin said. "There is no safe industry anymore, even here."

But an unprecedented number of high technology start-ups, easily 25 and possibly exceeding 40, are valued at $1 billion or more. Many employees are quietly getting rich, or at least building a big cushion against a crash, as they sell shares to outside investors. Airbnb, Pinterest, SurveyMonkey and Spotify are among the better-known privately held companies that have reached $1 billion. But many more with less familiar names, including Box, Violin Memory and Zscaler, are selling services to other companies.

"A year from now that might be 100," said Jim Goetz, a partner at Sequoia Capital, a venture capital business. Sequoia counts a dozen such companies in its portfolio. It is part of what he calls "a permanent change" in the way people are building their companies and financers are pushing up values.

(Read More: The Key to Staying Successful Online: Silicon Valley CEO)

The owners of these companies say the valuations make them giddy, but also create unease. Once $1 billion was a milestone, now it is also a millstone. Bigger expectations must be managed and greater uncertainty looms.

Investors and executives point to a number of reasons for the high valuations. Interest rates are low, which makes it easy for private equity companies to take large stakes in companies. Young tech millionaires and wealthy foreigners like Yuri Milner, the Russian billionaire, have been private investors, too. As each one puts more money into a start-up, it escalates the bidding for the others.

Last month the value of Twitter, which began in 2006, hit $9 billion, based on an offer for employee shares by BlackRock, a global investment manager. On the first day Microsoft sold shares to the public in 1986 it was 11 years old and worth just $778 million. That would be only $1.6 billion adjusted for inflation.

Pinterest, an online scrapbooking and social networking site with no revenue, became worth $1.5 billion in less than three years. Amazon.com went public in 1997 after only three years, but had a valuation of just $438 million. And it had almost $16 million in revenue for the 1997 fiscal year.

Silicon Valley entrepreneurs contend that the price spiral is not a sign of another tech bubble. The high prices are reasonable, they say, because innovations like smartphones and cloud computing will remake a technology industry that is already worth hundreds of billions of dollars.

In addition, many of the billion-dollar companies, including MobileIron, Pure Storage, Marketo, DDS and SurveyMonkey (which two weeks ago raised $794 million, to reach a value of $1.35 billion), sell products and services primarily to other businesses.

For every Dropbox, which offers online data storage primarily to consumers and is valued at $4 billion, there are two unheralded companies like Zscaler, a provider of online corporate data security, and Palantir, which does predictive data analysis, valued at more than $1 billion. Selling to big business is considered less risky than selling to consumers.

(Read More: Pushing France Onto the Digital Stage)

"There are disruptions everywhere," said Robert Tinker, the chief executive of MobileIron, which makes software for companies to manage smartphones and tablets. "Mobile disrupts personal computers, a market worth billions. Cloud disrupts computer servers and data storage, billions of dollars more. Social may be one of those rare things that is totally new."

Relative to the size of the markets that mobile devices, cloud computing and social media are toppling, he says, the valuations are reasonable.

But most of these chief executives are also veterans of the Internet bubble of the late '90s, and confess to worries that maybe things are not so different this time. Mr. Tinker, 43, drives a 1995 Ford Explorer that has logged 265,000 miles.

"If somebody comes to a job interview here in a $100,000 car, I know he's not hungry," he said. "The reality is, I've taken $94 million in investors' money, and we haven't gone public yet. I feel that responsibility every day."

Concern is growing that the billion-plus club is filling up with companies that look alike. "Everyone is saying, 'I have a cloud technology, I should be valued at 20 times my sales,' " said Jay Chaudhry, the chief executive of Zscaler. "Some are real, but a lot of others are stretched too thin. They'll languish out there."

The nagging fear is that valuations, which are turned into profits only if the company goes public successfully or is bought for a high price, could still plunge.

(Read More: US Tech Groups Criticized for EU Lobbying)

Groupon, the daily deals site, rejected a $6 billion acquisition offer from Google in 2010. After going public, it is valued at $3 billion. Zipcar, a car-sharing service, was worth $1.2 billion at its April 2011 initial public offering. In January, Avis Budget Group bought it for just $500 million.

Facebook's stock debut, of course, is the greatest valuation warning of all. It was modestly higher on its first day of public trading and down by about half four months later. Facebook has since recovered somewhat, but other executives now call its initial public offering "Faceplant."

Source: http://www.cnbc.com/id/100433330

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New modeling approach transforms imaging technologies

Feb. 5, 2013 ? Researchers are improving the performance of technologies ranging from medical CT scanners to digital cameras using a system of models to extract specific information from huge collections of data and then reconstructing images like a jigsaw puzzle.

The new approach is called model-based iterative reconstruction, or MBIR.

"It's more-or-less how humans solve problems by trial and error, assessing probability and discarding extraneous information," said Charles Bouman, Purdue University's Michael and Katherine Birck Professor of Electrical and Computer Engineering and a professor of biomedical engineering.

MBIR has been used in a new CT scanning technology that exposes patients to one-fourth the radiation of conventional CT scanners. In consumer electronics, a new camera has been introduced that allows the user to focus the picture after it has been taken.

"These innovations are the result of 20 years of research globally to develop iterative reconstruction," Bouman said. "We are just scratching the surface. As the research community builds more accurate models, we can extract more information to get better results."

In medical CT scanners, the reduction of radiation exposure is due to increased efficiency achieved via the models and algorithms. MBIR reduces "noise" in the data, providing greater clarity that allows the radiologist or radiological technician to scan the patient at a lower dosage, Bouman said.

"It's like having night-vision goggles," he said. "They enable you to see in very low light, just as MBIR allows you to take high-quality CT scans with a low-power X-ray source."

Researchers also have used the approach to improve the quality of images taken with an electron microscope. New findings are detailed in a research paper being presented during the Electronic Imaging 2013 conference in San Francisco this week.

Traditionally, imaging sensors and software are designed to detect and measure a particular property. The new approach does the inverse, collecting huge quantities of data and later culling specific information from this pool of information using specialized models and algorithms.

"We abandon the idea of purity -- collecting precisely what we need," Bouman said. "Instead, let's take all the measurements we possibly can and then later extract what we want. This increases the envelope of what you can do enormously."

Purdue, the University of Notre Dame and GE Healthcare used MBIR to create Veo, a new CT scanning technology that enables physicians to diagnose patients with high-clarity images at previously unattainable low radiation dose levels. The technology has been shown to reduce radiation exposure by 78 percent.

"If you can get diagnostically usable scans at such low dosages this opens up the potential to do large-scale screening for things like lung cancer," Bouman said. "You open up entirely new clinical applications because the dosage is so low."

A CT scanner is far better at diagnosing disease than planar X-rays because it provides a three-dimensional picture of the tissue. However, conventional CT scanners emit too much radiation to merit wider diagnostic use.

"But as the dosage goes down, the risk-benefit tradeoff for screening will become much more favorable," Bouman said. "For electron microscopy, the principle advantage is higher resolutions, but there is also some advantage in reduction of electron dosage, which can damage the sample."

The research to develop Veo has been a team effort with Ken Sauer, an associate professor of electrical engineering at Notre Dame, in collaboration with Jean-Baptiste Thibault, Jiang Hsieh and Zhou Yu. Thibault and Yu worked on the technology as graduate assistants under Bouman and Sauer and both currently work for GE Healthcare.

"And, there are lots of other people doing similar and related research at other universities and research labs around the world," Bouman said."Ultimately, 3-D X-ray CT images might require little more dosage than old-fashion planar chest X-rays. This would allow CT to be used for medical screening without significant adverse effects."

In the electron microscope research, MBIR was used to take images of tiny beads called aluminum nanoparticles.

"We are getting reconstruction quality that's dramatically better than was possible before, and we think we can improve it even further," Bouman said.

Improved resolution could help researchers design the next generation of nanocomposites for applications such as fuel cells and transparent coatings.

The paper was authored by Purdue doctoral student Singanallur Venkatakrishnan; U.S. Air Force Research Laboratory researchers Lawrence Drummy and Jeff Simmons; Michael Jackson, a researcher from BlueQuartz Software; Carnegie Mellon University researcher Marc De Graef; and Bouman. A tutorial article (pdf) also appeared in January in the journal Current Radiological Reports.

The models and algorithms in MBIR apply probability computations to extract the correct information, much as people use logical assumptions to draw conclusions.

"You search all possible data to find what you are looking for," Bouman said. "This is how people solve problems. You saw Bob yesterday at the store; you wonder where he was coming from. Well, you determine that he was probably coming from work because you have some probabilistic models in your mind. You know he probably wasn't coming from San Francisco because Bob doesn't go to San Francisco very often, etc."

MBIR also could bring more affordable CT scanners for airport screening. In conventional scanners, an X-ray source rotates at high speed around a chamber, capturing cross section images of luggage placed inside the chamber. However, MBIR could enable the machines to be simplified by eliminating the need for the rotating mechanism.

Future research includes work to use iterative reconstruction to study materials. Purdue is part of a new Multi-University Research Initiative funded by the U.S. Air Force and led by De Graef. Researchers will use the method to study the structure of materials, work that could lead to development of next-generation materials.

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The above story is reprinted from materials provided by Purdue University. The original article was written by Emil Venere.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/most_popular/~3/DidVzAKxZ1s/130205143415.htm

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Make Better Decisions by Pretending You're Advising a Friend

Make Better Decisions by Pretending You're Advising a FriendWhen you're faced with a tough choice, it's easy to let emotions get in the way and cloud your decision. The New York Times suggests that one way to get over this is to pretend you're advising a friend on what should do.

The idea here is to distance yourself from the decision, which is easier said than done. However, if you consider it as advice you'd give, you can get yourself out of your own head for a minute:

When short-term emotions threaten to swamp long-term considerations, [author] Chip Heath suggests that a simple yet highly effective way to think about a difficult decision is to consider what you would recommend to your best friend.

"When we step back and simulate someone else, it's a clarifying move," he said.

Distancing yourself is always good for making a decision, and this is one way to reframe the choice and consider it from another angle so you don't have a natural reaction that prevents a good decision.

When You Don't Do What You Meant To, and Don't Know Why | The New York Times

Photo by Alex Guerrero.

Source: http://feeds.gawker.com/~r/lifehacker/full/~3/RnqbmmE554E/make-better-decisions-by-pretending-youre-advising-a-friend

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Tuesday, February 5, 2013

Legal argument for drone strikes on Americans

Khaled Abdullah / Reuters file

Tribesmen examine the rubble of a building in southeastern Yemen where American teenager Abdulrahmen al-Awlaki and six suspected al-Qaida militants were killed in a U.S. drone strike on Oct. 14, 2011. Al-Awlaki, 16, was the son of Anwar al-Awlaki, who died in a similar strike two weeks earlier.

By Michael IsikoffNational Investigative Correspondent, NBC News

A confidential Justice Department memo concludes that the U.S. government can order the killing of American citizens if they are believed to be ?senior operational leaders??of al-Qaida or ?an associated force? -- even if there is no?intelligence?indicating they?are?engaged in an active plot to attack the U.S.

The 16-page memo, a copy of which was obtained?by NBC News, provides new details?about the legal reasoning behind one of the Obama administration?s most secretive and controversial polices: its dramatically increased use of drone strikes against al-Qaida suspects, including those aimed at American citizens, such as the? September 2011 strike in Yemen that killed alleged al-Qaida operatives Anwar al-Awlaki and Samir Khan. Both were U.S. citizens who had never?been indicted by the U.S. government nor charged with any crimes.??

The secrecy surrounding such strikes is fast emerging as a central issue in this week?s hearing of White House counterterrorism adviser John Brennan, a key architect of the drone campaign, to be CIA director.??Brennan was the first administration official to publicly acknowledge drone strikes in a speech last year, calling them ?consistent with the inherent right of self-defense.? In a separate talk at the Northwestern University Law School in March, Attorney General Eric Holder?specifically endorsed the constitutionality of?targeted killings of Americans, saying they could be justified if government officials determine the target?poses? ?an imminent threat of violent attack.?


But the confidential?Justice Department ?white paper??introduces a more expansive definition of self-defense or imminent attack than described? by Brennan or Holder in their public speeches.? It refers, for example,?to what it calls a ?broader concept of imminence? than actual intelligence about any ongoing plot against the U.S. homeland. ? ?

Michael Isikoff, national investigative correspondent for NBC News, talks with Rachel Maddow about a newly obtained, confidential Department of Justice white paper that hints at the details of a secret White House memo that explains the legal justifications for targeted drone strikes that kill Americans without trial in the name of national security.

?The condition that an operational? leader present an ?imminent? threat of violent attack against the United States does not require the United States to have clear evidence that a specific attack on U.S. persons and interests will take place in the immediate future,? the memo states.

Read the entire 'white paper' on drone strikes on Americans

Instead, it says,? an ?informed, high-level? official of the U.S. government may determine that the targeted American? has been ?recently? involved in ?activities? posing a threat of a violent attack and ?there is? no evidence suggesting that he has renounced or abandoned such activities.? The memo does not define ?recently? or ?activities.??

As in Holder?s speech, the confidential?memo lays out a three-part test that would make targeted killings of American lawful: ?In addition to the suspect being an imminent threat, capture of the target must be ?infeasible, and the strike must be conducted according to ?law of war principles.? But the memo elaborates on some of these factors in ways that go beyond what the attorney general said publicly. For example, it states that U.S. officials may consider whether an attempted capture of a suspect? would?pose an ?undue risk? to U.S. personnel involved in such an operation. If so, U.S. officials could determine that the capture operation of the targeted American would not be feasible, making it lawful for the U.S. government to order a killing instead, the memo concludes.

The?undated?memo is entitled ?Lawfulness of a Lethal Operation Directed Against a U.S. Citizen who is a Senior Operational Leader of Al Qa?ida or An Associated Force.?? It was provided to members of the Senate Intelligence and Judiciary committees?in June by administration officials on the condition that it be kept confidential and? not discussed publicly.

Although not an official legal memo, the white paper was represented by administration? officials as a policy document that closely?mirrors the arguments of classified memos on targeted killings by the Justice Department?s? Office of Legal Counsel, which provides authoritative legal advice to the president and all executive branch agencies. The administration has refused to turn over to Congress or release those memos publicly -- or even publicly confirm their existence. A source with access to the white paper, which is not classified,?provided a copy to NBC News.?

?This is a chilling document,? said Jameel Jaffer, deputy legal director of the ACLU, which is suing to obtain administration memos about the targeted killing of Americans.? ?Basically, it argues that the government has the right to carry out the extrajudicial killing of an American citizen. ? It recognizes some limits on the authority it sets out, but the limits are elastic and vaguely defined, and it?s easy to see how they could be manipulated.?

In particular, Jaffer said, the memo ?redefines?the word imminence in a way that deprives the word of its ordinary meaning.???

A Justice Department spokeswoman declined to comment on the white paper. The spokeswoman, Tracy Schmaler, instead pointed to public speeches by what she called a ?parade? of administration officials, including Brennan, Holder, former State Department Legal Adviser Harold Koh and former Defense Department General Counsel Jeh Johnson that she said outlined the ?legal framework? for such operations.?

Pressure for turning over the Justice Department memos on targeted killings?of Americans appears to be building on Capitol Hill amid?signs that Brennan will be grilled on the subject at his confirmation hearing before the Senate Intelligence Committee on Thursday.?

On Monday, a bipartisan group of 11 senators -- led by Democrat Ron Wyden of Oregon ? wrote? a letter to President Barack Obama asking him to release all Justice Department memos on the subject.?While accepting that ?there will clearly be circumstances in which the president has the authority to use lethal force? against Americans who take up arms against the country, ?it said, ?It is vitally important ... for Congress and the American public to have a full understanding of how? the executive branch interprets the limits and boundaries of this authority.?

Anticipating domestic boom, colleges rev up drone piloting programs

The completeness of the administration?s public accounts of its legal arguments was also sharply criticized last month by U.S. Judge Colleen McMahon in response to a? lawsuit brought by the New York Times and the ACLU seeking access to the Justice Department memos on drone strikes targeting Americans under the Freedom of Information Act.? McMahon, describing herself as being caught in a ?veritable Catch-22,?? said she was unable to order the release of the documents given ?the thicket of laws and precedents that effectively allow the executive branch of our government to proclaim as perfectly lawful certain actions that seem on their face incompatible with our Constitution and laws while keeping the reasons for the conclusion a secret.?

In her ruling, McMahon noted that administration officials ?had engaged in public discussion of the legality of targeted killing, even of citizens.? But, she wrote, they have done so ?in cryptic and imprecise ways, generally without citing ? any statute or court decision that justifies its conclusions.?

In one passage in Holder?s speech at Northwestern in March,? he alluded ? without spelling out?that there might be circumstances where the president might order attacks against American citizens without specific knowledge of when or where an attack against the U.S. might take place.

?The Constitution does not? require the president to delay action until some theoretical end-stage of planning, when the precise time, place and manner of an attack become clear,?? he said.

But his speech did not contain the additional language in the white paper suggesting that?no active intelligence about a specific attack is needed?to justify a targeted strike. Similarly, Holder said in his speech that targeted killings of Americans can be justified? if ?capture is not feasible.? But he did not include language in the white paper saying that an operation might not be feasible ?if it could not be physically effectuated during the relevant window of opportunity or?if the relevant country (where the target is located) were to decline to consent to a capture operation.? The speech also made no reference to the risk that might be posed to U.S. forces seeking to capture a target, as was ?mentioned in the white paper.?

The white paper also includes a more extensive discussion of why targeted strikes against Americans does not violate constitutional protections afforded American citizens as well as?? a U.S. law that criminalizes the killing of U.S. nationals overseas.

It??also discusses why such targeted killings would not be a war crime or violate a U.S. executive order banning?assassinations.

??A lawful killing in self-defense is not an assassination,? the white paper reads. ?In the Department?s view, a lethal operation conducted against a U.S. citizen whose conduct poses an imminent threat of violent attack against the United States would be a legitimate act of national self-defense that would not violate the assassination ban. Similarly,? the use of lethal force, consistent with the laws of war, against an individual who is a legitimate military target would be lawful and would not violate the assassination ban.?

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Source: http://openchannel.nbcnews.com/_news/2013/02/04/16843014-exclusive-justice-department-memo-reveals-legal-case-for-drone-strikes-on-americans?lite

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